Pinterest Pin for Mediterranean Artichoke and Chicken Casserole

This Mediterranean Artichoke and Chicken Casserole is a delightful and healthy chicken casserole, perfect for a weeknight meal. You’ll love how easy it is to prepare and how much flavor it packs into every bite. This dish is hearty, satisfying, and a great way to enjoy a wholesome meal.

Key Ingredients & Substitutions

  • Chicken: Boneless, skinless chicken breasts or thighs work best. You can use pre-cooked rotisserie chicken to save time.
  • Artichoke Hearts: Canned or jarred (packed in water, not oil) are convenient. Frozen artichoke hearts can also be used.
  • Spinach: Fresh spinach is ideal. Frozen chopped spinach, thawed and squeezed dry, also works well.
  • Feta Cheese: Crumbled feta adds a tangy kick. You can substitute with goat cheese or a dairy-free alternative.
  • Greek Yogurt: Plain, unsweetened Greek yogurt provides creaminess. Sour cream can be used in a pinch.
  • Diced Tomatoes: Canned diced tomatoes, undrained, are a staple. Fire-roasted diced tomatoes add extra depth.

Ingredients

Main Ingredients:

  • 1 tablespoon olive oil
  • 1.5 pounds boneless, skinless chicken breast, cut into 1-inch cubes
  • 1 large onion, chopped
  • 2 cloves garlic, minced
  • 1 (14.5 ounce) can diced tomatoes, undrained
  • 1 (14 ounce) can artichoke hearts, drained and chopped
  • 5 ounces fresh spinach
  • 1/2 cup plain Greek yogurt
  • 1/2 cup crumbled feta cheese
  • 1/4 cup chicken broth
  • 1/4 cup chopped fresh parsley (for garnish, optional)

Spices:

  • 1 teaspoon dried oregano
  • 1/2 teaspoon salt
  • 1/4 teaspoon black pepper

How Much Time Will You Need?

  • Total Time: 45 minutes
  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Servings: 6
  • Calories per serving: Approximately 320 calories
  • Tools Needed: Large oven-safe skillet or 9×13 inch baking dish, mixing bowls

Step-by-Step Instructions

1. Sauté the Aromatics

Heat olive oil in a large, oven-safe skillet over medium heat. Add the chopped onion and cook until softened, about 5 minutes. Stir in the minced garlic and cook for another minute until fragrant.

2. Cook the Chicken

Add the cubed chicken to the skillet with the onion and garlic. Cook until the chicken is lightly browned on all sides, about 5-7 minutes. You don’t need to cook it all the way through, as it will finish cooking in the oven.

3. Combine Casserole Ingredients

Stir in the diced tomatoes (undrained), chopped artichoke hearts, fresh spinach, Greek yogurt, feta cheese, chicken broth, oregano, salt, and pepper. Mix everything together until the spinach wilts and all ingredients are well combined.

4. Bake to Perfection

If your skillet is oven-safe, transfer it directly to a preheated oven. Otherwise, pour the mixture into a 9×13 inch baking dish. Bake at 375°F (190°C) for 20-25 minutes, or until the chicken is cooked through and the casserole is bubbly.

5. Garnish and Serve

Remove the healthy chicken casserole from the oven. Garnish with fresh chopped parsley, if desired. Let it sit for a few minutes before serving.

Variation Ideas

  • Add More Veggies: Include chopped bell peppers, zucchini, or eggplant for extra nutrients.
  • Grain Boost: Stir in 1 cup of cooked quinoa or brown rice before baking for a heartier meal.
  • Spicy Kick: A pinch of red pepper flakes will add a nice heat.
  • Different Cheeses: Try a sprinkle of mozzarella or Parmesan on top during the last 10 minutes of baking.

Storage Instructions

Store leftover Mediterranean Artichoke and Chicken Casserole in an airtight container in the refrigerator for up to 3-4 days. To reheat, you can microwave individual portions or warm the entire casserole in an oven preheated to 350°F (175°C) until heated through.

Frequently Asked Questions (FAQ)

Can I prepare this casserole ahead of time?

Yes, you can assemble the casserole and store it covered in the refrigerator for up to 24 hours before baking. Add a few extra minutes to the baking time if baking from cold.

What kind of chicken is best for this healthy chicken casserole?

Boneless, skinless chicken breasts or thighs both work well. Thighs tend to stay a bit juicier.

Can I use frozen spinach?

Absolutely! Just make sure to thaw it completely and squeeze out all excess water before adding it to the casserole.

Is this recipe gluten-free?

Yes, this Mediterranean Artichoke and Chicken Casserole recipe is naturally gluten-free.

How can I make this casserole dairy-free?

You can omit the feta cheese and use a plain, unsweetened dairy-free yogurt alternative.

What should I serve with this casserole?

It’s delicious on its own, but you can also serve it with a side salad, whole grain bread, or a simple grain like quinoa or couscous.